Readings on Frailty

Interested in frailty? Here are some informative readings:




2. Other Articles:

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WHAT IS FRAILTY ABOUT?punto interrogativo 6906191


Capanna, A., Scarcella, P., Gilardi, F., Mancinelli, S., Palombi, L., Marazzi, M.C., Riccardi, F. and Liotta, G. (2018) Sensitivity and Specificity of a Short Questionnaire to Screen Frailty in the Community-Dwelling Older Population. Advances in Aging Research, 7, 52-63. Link to the article

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O. & Rockwood, K. (2013). Frailty in elderly people. Lancet (London, England), 381(9868), 752–62. Link to the article

Dent, E., Kowal, P. & Hoogendijk, E. O. (2016). Frailty measurement in research and clinical practice: A review. European Journal of Internal Medicine, 31, 3-10. Link to the article

Dury, S., Dierckx, E., Van Der Vorst, A., Van der Elst, M., Fret, B., Duppen, D., ... & Schols, J. (2018). Detecting frail, older adults and identifying their strengths: results of a mixed-methods study. BMC public health, 18(1), 191. Link to the article

Gwyther, H., Shaw, R., Dauden, E. A. J., D’Avanzo, B., Kurpas, D., Bujnowska-Fedak, M., ... & Holland, C. (2018). Understanding frailty: a qualitative study of European healthcare policy-makers’ approaches to frailty screening and management. BMJ open, 8(1). Link to the article

Ipsos, M. O. R. I. (2014). Understanding the lives of older people living with frailty–a qualitative investigation. London: Age UKLink to the report

Kim, Y., & Jang, S. N. (2018). Mapping the knowledge structure of frailty in journal articles by text network analysis. PloS one, 13(4), e0196104. Link to the article

Liotta, G., O’Caoimh, R., Gilardi, F., Proietti, M. G., Rocco, G., Alvaro, R., … & Marazzi, M. C. (2017) Assessment of frailty in community-dwelling older adults residents in the Lazio region (Italy): A model to plan regional community-based services. Archives of Gerontology and Geriatrics Volume 68, January–February 2017, Pages 1-7. Link to the article

Rodríguez-Mañas, L., Féart, C., Mann, G., Viña, J., Chatterji, S., Chodzko-Zajko, W., Vega, E. (2012). Searching for an operational definition of frailty: A Delphi method based consensus statement. The Frailty Operative Definition-Consensus Conference Project. The Journals of Gerontology: Series A, 68(1), 62-67. Link to the article

Schoenborn NL, Van Pilsum Rasmussen SE, Xue Q-L, Walston JD, McAdams-Demarco MA, Segev DL, Boyd CM: Older adults’ perceptions and informational needs regarding frailty. BMC Geriatrics 2018, 18(1):46. Link to the article

Stenholm, S., Ferrucci, L., Vahtera, J., Hoogendijk, E. O., Huisman, M., Pentti, J., ... & Kivimäki, M. (2018). Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies. The Journals of Gerontology: Series A. (in press) Link to the article









Bock, J., König, H., Brenner, H., Haefeli, W. E., Quinzler, R., Matschinger, H., Heider, D. (2016). Associations of frailty with health care costs – results of the ESTHER cohort study. BMC Health Services Research, 16(1). Link to the article

García-Nogueras, I., Aranda-Reneo, I., Peña-Longobardo, L. M., Oliva-Moreno, J. & Abizanda, P. (2016). Use of health resources and healthcare costs associated with frailty: The FRADEA study. The journal of nutrition, health & aging, 21(2), 207-214. Link to the article

Hajek, A., Bock, J. O., Saum, K. U., Matschinger, H., Brenner, H., Holleczek, B., ... & König, H. H. (2017). Frailty and healthcare costs—longitudinal results of a prospective cohort study. Age and ageing, 47(2), 233-241. Link to the article

Marazzi, M. C., Inzerilli, M. C., Madaro, O., Palombi, L., Scarcella, P., Orlando, S., Maurici, M., Liotta, G. (2015). Impact of the Community-Based Active Monitoring Program on the Long Term Care Services Use and In-Patient Admissions of the Over-74 Population. Advances in Aging Research. Link to the article   

Sirven, N.; Rapp, T. The cost of frailty in France. Eur. J. Health Econ. 2017, 18, 243–253. Link to the article     










Cadore, E. L., Rodríguez-Mañas, L., Sinclair, A. & Izquierdo, M. (2013). Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: A systematic review. Rejuvenation Research, 16(2), 105-114. Link to the article

Lee, S., Lee, C., Ory, M. G., Won, J., Towne, S. D., Wang, S., & Forjuoh, S. N. (2018). Fear of outdoor falling among community-dwelling middlexercise 21e-aged and older adults: the role of neighborhood environments. The Gerontologist, 58(6), 1065–1074. Link to the article

Nagai K, Miyamato T, Okamae A, Tamaki A, Fujioka H, Wada Y, Uchiyama Y, Shinmura K, Domen K: Physical activity combined with resistance training reduces symptoms of frailty in older adults: A randomized controlled trial. Archives of Gerontology and Geriatrics 2018, 76:41-47. Link to the article  

Rogers NT, Marshall A, Roberts CH, Demakakos P, Steptoe A, Scholes S: Physical activity and trajectories of frailty among older adults: Evidence from the English Longitudinal Study of Ageing. PLoS ONE 2017, 12(2): e0170878. Link to the article

Susanto M, Hubbard RE, Gardiner PA: Twelve-Year Trajectories of Sitting Time are Associated With Frailty in Middle-Aged Women. American Journal of Epidemiology 2018:kwy111-kwy111. Link to the article

Theou, O., Stathokostas, L., Roland, K. P., Jakobi, J. M., Patterson, C. Vandervoort, A. A. & Jones, G. R. (2011). The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review. Journal of Aging Research, 2011, 1-19. Link to the article








balanced diet for men main image 700 350WHAT IS THE IMPORTANCE OF NUTRITION IN FRAILTY?

Bruyère, O., Cavalier, E., Buckinx, F. & Reginster, J. (2017). Relevance of vitamin D in the pathogenesis and therapy of frailty. Current Opinion in Clinical Nutrition and Metabolic Care, 20(1), 26-29. Link to the article

Cesari, M., Nobili, A. & Vitale, G. (2016). Frailty and sarcopenia: From theory to clinical implementation and public health relevance. European Journal of Internal Medicine, 35, 1-9. Link to the article

Goisser, S., Guyonnet, S. & Volkert, D. (2016). The role of nutrition in frailty: An overview. The Journal of Frailty & Aging, 5(2), 74–77. Link to the article

Laclaustra M, Rodriguez-Artalejo F, Guallar-Castillon P, Banegas JR, Graciani A, Garcia-Esquinas E, Ordovas J, Lopez-Garcia E: Prospective association between added sugars and frailty in older adults. The American Journal of Clinical Nutrition 2018, 107(5):772-779. Link to the article

León-Muñoz, L. M., Guallar-Castillón, P., López-García, E. & Rodríguez-Artalejo, F. (2014). Mediterranean diet and risk of frailty in community-dwelling older adults. Journal of the American Medical Directors Association, 15(12), 899-903. Link to the article

Lorenzo-López L, Maseda A, de Labra C, Regueiro-Folgueira L, Rodríguez-Villamil JL, Millán-Calenti JC: Nutritional determinants of frailty in older adults: A systematic review. BMC Geriatrics 2017, 17(108). DOI: Link to the article











BritainThinks (2015) Frailty: Language and Perceptions. A report prepared by BritainThinks on behalf of Age UK and the British Geriatrics Society. London: Age UK. Link to the reportStop hand

Ministry of Health Spain (2014). Consensus document on frailty and falls prevention among the elderly. The prevention and health promotion strategy of the Spanish NHS. Available at:Stop hand. Link to the article

Morley, J. E., Vellas, B., Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., Walston, J. (2013). Frailty consensus: A call to action. Journal of the American Medical Directors Association, 14(6), 392-397. Link to the article

National Institute for Health and Care Excellence (NICE) (2015). Dementia, disability and frailty in later life – mid-life approaches to delay or prevent onset. NICE Guideline [NG16]. Link to the article

National Institute for Health Research (NIHR) & NIHR Dissemination Centre (2018). HELP AT HOME - Use of assistive technology for older people review (2018). NIHR Themed Review. Link to the article

Puts, M. T., Toubasi, S., Andrew, M. K., Ashe, M. C., Ploeg, J., Atkinson, E., Mcgilton, K. (2017). Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age and Ageing. Link to the article









Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D: Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts. The Journals of Gerontology: Series A 2018. Link to the article

Brunner EJ, Shipley MJ, Ahmadi-Abhari S, Valencia Hernandez C, Abell JG, Singh-Manoux A, Kawachi I, Kivimaki M: Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study. The Lancet Public Health 2018, 3(7):e313-e322. Link to the article

Dani M, Owen LH, Jackson TA, Rockwood K, Sampson EL, Davis D: Delirium, Frailty, and Mortality: Interactions in a Prospective Study of Hospitalized Older People. The Journals of Gerontology: Series A 2018, 73(3):415-418. Link to the article

Denfeld, Q. E., Winters-Stone, K., Mudd, J. O., Gelow, J. M., Kurdi, S., & Lee, C. S. (2017). The prevalence of frailty in heart failure: A systematic review and meta-analysis. International journal of cardiology, 236, 283-289. Link to the article

European Union (2017). The 2018 Ageing Report: Underlying assumptions & projection methodologies. Luxembourg: Publications Office of the European Union. European Commission, Directorate-General for Economic and Financial Affairs, Brussels. Link to the article

Gilardi, F., Scarcella, P., Proietti, M. G., Capobianco, G., Rocco, G., Capanna, A., ... & Liotta, G. (2018). Frailty as a predictor of mortality and hospital services use in older adults: a cluster analysis in a cohort study. European Journal of Public Health. Link to the article

Gale CR, Westbury L, Cooper C: Social isolation and loneliness as risk factors for the progression of frailty: the English Longitudinal Study of Ageing. Age and Ageing 2018, 47(3): 392–397. DOI: Link to the article

Gilbert T, Neuburger J, Kraindler J, Keeble E, Smith P, Ariti C, Arora S, Street A, Parker S, Roberts HC et al: Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study. The Lancet 2018, 391(10132):1775-1782. Link to the article

Herr, M., Arvieu, J. J., Ankri, J., & Robine, J. M. (2018). What is the duration of life expectancy in the state of frailty? Estimates in the SIPAF study. European journal of ageing, 15(2), 165-173. Link to the article

Hoeksema AR, Spoorenberg S, Peters LL, Meijer H, Raghoebar GM, Vissink A, Wynia K, Visser A: Elderly with remaining teeth report less frailty and better quality of life than edentulous elderly: a cross-sectional study. Oral Diseases (2017) 23, 526–536 doi:10.1111/odi.12644. Link to the article.

Hopwood, J., Walker, N., McDonagh, L., Rait, G., Walters, K., Iliffe, S., ... & Davies, N. (2018). Internet-Based Interventions Aimed at Supporting Family Caregivers of People With Dementia: Systematic Review. Journal of medical Internet research, 20(6), e216. Link to the article

Janssens, Barbara & Vanobbergen, Jacques & Petrovic, Mirko & Jacquet, Wolfgang & Schols, Jos M.G.A. & Visschere, Luc. (2017). The oral health condition and treatment needs of nursing home residents in Flanders (Belgium). Community dental health. 34. 143-151. 10.1922/CDH_4086Janssens09. Link to the article.

Janssens B, De Visschere L, van der Putten GJ, de Lugt-Lustig K, Schols JM, Vanobbergen J: Effect of an oral healthcare protocol in nursing homes on care staffs’ knowledge and attitude towards oral health care: a cluster-randomised controlled trial. Gerodontology. 2014 Nov 26. doi: 10.1111/ger.12164. Link to the article

Janssens, B., Petrovic, M., Jacquet, W., Schols, J. M. G. A., Vanobbergen, J., & De Visschere, L. (2017). Medication Use and Its Potential Impact on the Oral Health Status of Nursing Home Residents in Flanders (Belgium). Journal of the American Medical Directors Association, 18(9), 809.e1-809.e8. Link to the article.

Janssens B, Vanobbergen J, Lambert M, Schols JM, De Visschere L (2017) Effect of an oral healthcare programme on care staff knowledge and attitude regarding oral health: a non-randomised intervention trial. Clinical Oral Investigations 22:281–292. Link to the article

Janssens B, Vanobbergen J, Petrovic M, Jacquet W, Schols JM, De Visschere L (2018) The impact of a preventive and curative oral healthcare program on the prevalence and incidence of oral health problems in nursing home residents. PLoS ONE 13(6): e0198910. doi: 10.1371/journal.pone.0198910. Link to the article

Kamdem, B., Seematter-Bagnoud, L., Botrugno, F., & Santos-Eggimann, B. (2017). Relationship between oral health and Fried’s frailty criteria in community-dwelling older persons. BMC Geriatrics, 17(1), 174. Link to the article

Keränen, N. S., Kangas, M., Immonen, M., Similä, H., Enwald, H., Korpelainen, R., & Jämsä, T. (2017). Use of information and communication technologies among older people with and without frailty: a population-based survey. Journal of medical Internet research, 19(2). Link to the article

Kojima G., Iliffe S., Jivraj S., Liljas A., Walters K. (2018). Does current smoking predict future frailty? The English longitudinal study of ageing. Age and Ageing, 47(1),126-131. Link to the article

Kojima, G., Iliffe, S., Jivraj, S., & Walters, K. (2016). Association between frailty and quality of life among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health, 70(7), 716-721. Link to the article

Liotta G, Canhao H, Cenko F, Cutini R, Vellone E, Illario M, Kardas P, Poscia A, Dinis Sousa R, Palombi L, and Marazzi M C: Active Ageing in Europe: Adding Healthy Life to Years. Frontiers in Medicine, 30 April 2018. Link to the article

MacEntee I, Michael & Donnelly, Leeann. (2016). Oral health and the frailty syndrome. Periodontology 2000. 72. 135-141. 10.1111/prd.12134. Link to the article.

McDonagh J, Martin L, Ferguson C, Jha SR, Macdonald PS, Davidson PM, Newton PJ: Frailty assessment instruments in heart failure: A systematic review. European Journal of Cardiovascular Nursing 2018, 17(1):23-35. Link to the article

Poli, S., Cella, A., Puntoni, M., Musacchio, C., Pomata, M., Torriglia, D., ... & Pilotto, A. (2017). Frailty is associated with socioeconomic and lifestyle factors in community-dwelling older subjects. Aging clinical and experimental research, 29(4), 721-728. Link to the article

Redding, D., Gentry, T., Shand, J., Stuart, L. (2014) I'm Still Me…A Narrative for Coordinated Support for Older People. Link to the report

Ringer, T., Hazzan, A. A., Agarwal, A., Mutsaers, A., & Papaioannou, A. (2017). Relationship between family caregiver burden and physical frailty in older adults without dementia: a systematic review. Systematic reviews, 6(1), 55. Link to the article

Saum, K. U., Schöttker, B., Meid, A. D., Holleczek, B., Haefeli, W. E., Hauer, K., & Brenner, H. (2017). Is polypharmacy associated with frailty in older people? Results from the ESTHER cohort study. Journal of the American Geriatrics Society, 65(2), e27-e32. Link to the paper

Soysal P, Veronese N, Thompson T, Kahl KG, Fernandes BS, Prina AM, Solmi M, Schofield P, Koyanagi A, Tseng P-T et al: Relationship between depression and frailty in older adults: A systematic review and meta-analysis. Ageing Research Reviews 2017, 36:78-87. Link to the article

Takada S, Yamamoto Y, Shimizu S, Kimachi M, Ikenoue T, Fukuma S, Onishi Y, Takegami M, Yamazaki S, Ono R et al: Association Between Subjective Sleep Quality and Future Risk of Falls in Older People: Results From LOHAS. The Journals of Gerontology: Series A 2018, 73(9):1205-1211. Link to the article

Walston J: Frailty Research Moves Beyond Risk Assessment. The Journals of Gerontology: Series A 2017, 72(7):915-916. Link to the article

Willard, S., Cremers, G., Man, Y. P., van Rossum, E., Spreeuwenberg, M., & de Witte, L. (2018). Development and testing of an online community care platform for frail older adults in the Netherlands: a user-centred design. BMC geriatrics, 18(1), 87. Link to the article

World Health Organization (2015). World report on ageing and health. Luxembourg. Link to the article

World Health Organization (2017). Integrated Care for Older People (ICOPE). Guidelines on community-level interventions to manage declines in intrinsic capacity. Switzerland. Link to the article